Ovarian meiotic prophase and the fetal pituitary in the rat.

in studies on teratogenesis. Fetuses afflicted with holoprosencephaly, including varying degrees of such malformations as pituitary agenesis, cyclocephaly, cyclopia and monorhinia, can be obtained by administering triparanol or AY 9944 which inhibits cholesterol synthesis. A large number of fetuses have a minor form of holoprosencephaly, i.e. limited to isolated hypophyseal agenesis. We used these fetuses for gonadal study.